SELECTED PUBLICATIONS

Submitted and Published Papers

Zhao X. Gender and age differences in the hepatic consequences of “humanized” bile acid compositions in mice. Cell Mol Gastroenterol Hepatol, in press.


Zhao X, Wangensteen K. Inflammasome-more injury in cholestasis. Cell Mol Gastroenterol Hepatol 9(4):711-712, Feb 2020. Cited in Pubmed; PMID: 32156506.


Zhao X, Lorent K, Escobar-Zarate D, Ramakrishnan R, Loomes K, Gillespie K, Mesaros C, Estrada MA , Blair I, Winker J, Spinner N, Devoto M, Pack M. Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia. Gastroenterology 159(3):1068-1084, Sept 2020. Cited in Pubmed; PMID: 32505743.


Estrada MA, Lorent K, Kriegermeier A, Nagao SA, Berritt S, Wells RG, Pack M, Winkler JD.: Synthesis and structure-activity relationship study of biliatresone, a plant isoflavonoid that causes biliary atresia. 14(9): 61-64, Dec 2017. Cited in Pubmed; PMID: 29348813.


Zhao, X, Lorent K, Wilkins B, Marchione DM, Gillespie K, Waisbourd-Zinman O, So J, Koo KA, Shin D, Porter JR, Wells RG, Pack M.: Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology 64(3): 894-907, Sep 2016. Cited in Pubmed; PMID: 27102575.


Waisbourd-Zinman O, Koh H, Tsai S, Lavrut P, Dang C, Pack M, Cave J, Hawes M, Koo KA, Porter JR, Wells RG.: The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis via decreased glutathione and SOX17. 64(3): 880-93, Sep 2016. Cited in Pubmed; PMID: 27081925.


Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Sealy I, Kettleborough R, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG, Pack M.: Identification of a Plant Isoflavonoid that Causes Biliary Atresia. May 2015. Cited in Pubmed; PMID: 25947162.


Zhao X, Monson C, Gao C, Gouon-Evans V, Matsumoto N, Sadler KC, Friedman S: Klf6/copeb is required for endoderm development and hepatic outgrowth in zebrafish and mouse ES cells. Developmental Biology 344(1): 79-93, Aug 2010. Cited in Pubmed; PMID: 20430021.


Yea S, Narla G, Garg R, Tal-Kremer S, Hod, E, Villaneuva A, Like J, Tarocchi, M, Shirasawa S, Sasazuk T, Martignetti J, Llovet J, Friedman S.: Oncogenic Ras promotes cellular growth by enhancing alternative splicing-mediated inactivation of the KLF6 tumor suppressor. 134(5): 1521-31, May 2008. Cited in Pubmed; PMID: 18471523.


Narla G, Tal-Kremer S, Matsumoto N, Yao S, Kelley K, Tarocchi M, Friedman S.: In vivo regulation of p21 by the Klf6 tumor suppressor gene in mouse liver and human hepatocellular carcinoma. 26(30): 4428-34, Jun 2007. Cited in Pubmed; PMID: 17297474.